How cold plasma treatment with GEHWOL TECH works

How cold plasma treatment with GEHWOL TECH works

Controllability as the key to safety

The GEHWOL TECH cold plasma device is based on a grounded plasma process. A directed electromagnetic field is created between the device head and the skin, generating a structured plasma flow.

The central idea behind the safety-by-design principle is not maximum intensity, but rather the controllable dosage of the effect.

Controllable plasma flow – targeted effect

The treatment can be precisely adjusted using two parameters:

• Distance between the device head and the skin
• Treatment duration

This allows both the intensity and the ratio of active plasma components to be controlled. A short distance favours the proportion of reactive species and thus antimicrobial effects. As the distance increases, the effect shifts in favour of free electrons, which primarily support regenerative, antioxidant and electrophysiological processes.

Treatment safety and tolerability

The grounded mode of operation reduces undesirable side reactions such as ozone formation and keeps relevant limit values well below the maximum. The treatment remains cool, odourless and pleasant. The controllability of the plasma flow allows the application to be reproducibly adapted to different skin conditions – from sensitive to robust.

Practical advantages

• Contactless, hygienic application
• No consumables
• Simple operation
• Large treatment area
• Economical and sustainable

CONCLUSION

Cold plasma with GEHWOL TECH is not a trend, but a consistently physically conceived addition to existing treatment and care concepts. The technology combines antimicrobial effectiveness with skin-protecting and regenerative effects – controllable, safe and practical. For podiatry, foot care and cosmetics, it opens up new ways of treating skin and nails in a differentiated manner and combining prevention, therapy and care in a meaningful way.

Agenda

Cold plasma: controlled physics for skin, nails and microorganisms

• Cold plasma in podiatry
• Cold plasma in foot care & cosmetics
• How cold plasma treatment with GEHWOL TECH works

Literature review

(A) Antifungal effects of cold plasma

[1] Gnat, S., Łagowski, D., Dyląg, M. et al. Cold atmospheric pressure plasma (CAPP) as a new alternative treatment method for onychomycosis caused by Trichophyton verrucosum: in vitro studies. Infection 49, 1233–1240 (2021). https://doi.org/10.1007/s15010-021-01691-w
[2] S. R. Lipner, G. Friedman, R. K. Scher, Pilot study to evaluate a plasma device for the treatment of onychomycosis, Clinical and Experimental Dermatology, Volume 42, Issue 3, 1 April 2017, Pages 295–298, https://doi.org/10.1111/ced.12973
[3] Xiong, Z., Roe, J., Grammer, T.C. and Graves, D.B. (2016), Plasma Treatment of Onychomycosis. Plasma Process. Polym., 13: 588-597. https://doi.org/10.1002/ppap.201600010

(B) Hormesis effects and regenerative effects of cold plasma

[4] Schmidt A, Dietrich S, Steuer A, Weltmann KD, von Woedtke T, Masur K, Wende K. Non-thermal plasma activates human keratinocytes by stimulation of antioxidant and phase II pathways. J Biol Chem. 2015 Mar 13;290(11):6731-50. https://doi.org/10.1074/jbc.M114.603555
[5] von Woedtke, T., Schmidt, A., Bekeschus, S., Wende, K., & Weltmann, K.-D. (2019). Plasma Medicine: A Field of Applied Redox Biology. In Vivo, 33(4), 1011–1026. https://doi.org/10.21873/invivo.11570
[6] Ahn, G. R., Park, H. J., Koh, Y. G., Shin, S. H., Kim, Y. J., Song, M. G., Lee, J. O., Hong, H. K., Lee, K. B., & Kim, B. J. (2022). Low-intensity cold atmospheric plasma reduces wrinkles on photoaged skin through hormetic induction of extracellular matrix protein expression in dermal fibroblasts. Lasers in Surgery and Medicine, 54(7), 978–993. https://doi.org/10.1002/lsm.23559
[7] Schmidt, A., Bekeschus, S., Wende, K., Vollmar, B., & von Woedtke, T. (2017). A cold plasma jet accelerates wound healing in a murine model of full-thickness skin wounds. Experimental Dermatology, 26(2), 156–162. https://doi.org/10.1111/exd.13156
[8] Jung, J. M., Yoon, H. K., Won, C. H., Seo, Y. K., & Park, Y. W. (2021). Cold Plasma Treatment Promotes Full-thickness Healing of Skin Wounds in Murine Models. Journal of Experimental & Clinical Medicine, 13(2), 456–467. https://doi.org/10.1177/15347346211002144
[9] von Woedtke, T., Schmidt, A., Bekeschus, S., Wende, K., & Weltmann, K.-D. (2019). Plasma Medicine: A Field of Applied Redox Biology. In Vivo, 33(4), 1011–1026. https://doi.org/10.21873/invivo.11570
[10] Tan, F., Wang, Y., Zhang, S., Shui, R., & Chen, J. (2022). Plasma Dermatology: Skin Therapy Using Cold Atmospheric Plasma. Frontiers in Oncology, 12, 918484. https://doi.org/10.3389/fonc.2022.918484
[11] Busco, G., Robert, E., Chettouh-Hammas, N., Pouvesle, J.-M., & Grillon, C. (2020). The emerging potential of cold atmospheric plasma in skin biology. Free Radical Biology and Medicine, 161, 290–304. https://doi.org/10.1016/j.freeradbiomed.2020.10.004
[12] Choi, J. H., Song, Y. S., Song, K., Lee, H. J., Hong, J. W., & Kim, G. C. (2016). Skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes. Scientific Reports, 6, 27376. https://doi.org/10.1038/srep27376
[13] Kisch, T., Schleusser, S., Limpert, R., Seuser, A., Mailänder, P., Kraemer, R., & Arnemann, J. (2016). Initiation of microcirculation by cold atmospheric plasma. Wound Repair and Regeneration, 24(6), 1023–1030. https://doi.org/10.1111/wrr.12479